Here’s the difference: A bread that claims to be “whole wheat” means it’s made entirely from wheat kernel. Whole-grain bread, on the other hand, can be made with any type of whole-grain kernel, like oats, barley or spelt, or some mixture of those. In fact, both of those types of bread are good choices (as opposed to breads that don’t contain the word “whole” in the title, meaning the bread is made up of parts other than the whole kernel), but there are some differences. For example, whole-wheat bread contains whole-wheat flour that goes through a refining process that removes some of its nutritional value, while whole-grain flour is not refined and maintains all of its nutrients, including fiber, iron and vitamin B.